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Hou et al (2005) researched the autonomic effects of modafinil in humans. They observed that modafinil has an effect on the locus coeruleus, which mediates pupil diameter and arousal, but it does not have an impact on other autonomic features, which are controlled by noreadrenergic Manage facilities (A1 – A5) Situated beyond the locus coeruleus.S
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